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e-Science 2008 4th IEEE International Conference on e-Science

Exhibits, Demos & Posters

Coupling Computers to Living Cells for Automated Knowledge Extraction


  • Daniel Callahan, Live Cell Assays LLC, Martinez, CA


A general method for coupling individual living cells to computers is presented. This method is called Visual-Servoing Optical MicroscopyTM (VSOMTM). Protocols, instrumentation, and software are described and experimental results are presented. During VSOM experiments, automated decisions are made as single cell responses to computer-applied stimuli are interpreted in real-time. Well-annotated live cell responses are stored in distributed VSOM databases in real-time. This closed-loop method enables automated extraction of knowledge from individual living cells.

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